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CrossRef citations to date. 1. Altmetric. Listen. Original Articles. Protective effect of curcumin (Curcuma longa) against d-galactose-induced senescence in mice. Qena, Egypt, Tel: , Email: [email protected] Received Date: Sep 25, / Accepted Date: Aug 11, / Published Date: Keywords: Albino rats; Carbon tetrachloride; Ursodeoxycholic acid; Curcuma longa;. Jan 8, Objectives Curcuma zedoaria Rosc is a perennial herb found in an up‐to‐date and comprehensive review of C. zedoaria that covers its.
Regeneration was detected in the hepatic cells Figure 4. The hepatocytes displayed normal in the architecture of the hepatic cells adjacent to the central vein vacuolar degeneration in the hepatocytes with congestion in the central veins Figure 5. The kidneys in group 3 showed perivascular edema with congestion and hyalinization in the wall of the blood vessels Figure 6. The Liver in group 4 showed few fibrous tissues proliferation surrounded the blood vessels and bile ducts in the portal tract Figure 7.
The kidneys in group 4 showed congestion in the glomerular capillaries. The renal tubules displayed mild necrosis and degenerative changes. Hyalinization in the wall of the blood vessels was detected. The liver in group 5 showed congestion in the blood vessels, besides necrosis in few of hepatic cells. The Kidneys in group 5 showed congestion in the glomerular capillaries and periglomerular blood vessels Figure 8. According to [ 31 ], depletion in RBCs count and Hb content leads to iron deficiency anemia which is characterized by a microcytic hypochromic blood picture.
CCl4 induced a highly significant increase in WBCs count; this increase may be attributed to the defensive mechanism of immune system [ 33 ].
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Oral treatment with ursofalk drug group 3 and curcuma longa group 4 ameliorates the blood picture parameters which may be attributed to their antioxidant effects; since it has been shown that Ursodeoxycholic acid has antioxidative properties [ 34 ]. It is evident that curcuma longa may stabilize the cell membrane and restore various blood variables [ 35 ].
These elevations in the serum liver marker enzymes could be attributed to the free radicals which caused structural integrity damage of the liver cell membrane and hence a leakage of the cellular enzymes in to the blood [ 37 ]. The reduction in serum albumin control group is due to the hepatic injury which caused by CCl4 [ 38 ]. The significant reduction of all the serum liver enzymes and the significant increase in serum albumin in case of ursofalk drug has been attributed to its mechanism on membrane stabilizing [ 39 ].
Descubre los beneficios de la cúrcuma para tu piel
Curcum alonga may enhance the molecular mechanism of enzymes action; this could explain the reduction in serum liver enzymes [ 40 ]. The reduction in serum uric acid level in the present study may be attributed to the increased utilization of uric acid against increased production of the free radicals since it has a capable especially of reacting with free radicals [ 43 ].
Treatment with ursofalk drug group3 and curcuma longa group4 ameliorates the elevation of kidney functions parameters, as mentioned by Wong [ 44 ] Ursodeoxycholic acid is an antioxidant, and its vascular effects could be mediated via a reduction in oxidative stress. The improvements in renal function markers in group 4 may be due to the protective effect of curcumin against renal injury by suppressing oxidative stress, increasing kidney GSH content and gluthation peroxidase activity [ 45 ].
The present study declared that, administration of CCl4 induced a significant reduction in serum glucose compared with normal group this may be due to the decreased hepatic glycogen content after treatment with CCl4 which reflecting decreased gluconeogenesis by the liver [ 46 ].
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In group 4 curcuma longa improvement mechanism explained by Kanitkar [ 48 ] who stated that curcuminoid, which is component of turmeric, inhibited the formation of oxygen species associated with damage and dysfunction of langerhans islets.
The present results showed that CCl4 induced a highly significant increase in serum Cholesterol, Triglycerides and LDLCholesterol levels while serum HDL-Cholesterol level was significantly decreased, it has been shown that micro-viscosity of a membrane increase markedly with increases in cholesterol and phospholipids ratio thus leading to cellular rigidity.
Curcumin has also been linked to protection against cognitive decline, such as limiting the plaques that leads to neurological impairment in Alzheimer's disease.
While it seems promising, it's important to know that there simply isn't enough evidence from human trials just yet. The studies that have been done to-date are super small; one recent turmeric study showing tremendous potential had just three participants! Another recent study links curcuminoids to a possible reduced risk of cognitive decline, indicating that the spice as part of a meal can be beneficial rather than a curcurmin supplement alone.
That's why I'm a big proponent for using the spice when cooking - not in pill form. It sharpens your mind. While it may seem like a cure-all, turmeric can't help you get through a presentation you're unprepared for sorry - I wish! With that in mind, some preliminary research found that out of over 1, participants, elderly individuals who ate turmeric scored higher on test than those who rarely or never ate the stuff.
While loads more research is still needed, this finding may help convince your family to have more curry nights! It can help with autoimmune disorders. Most of the research done on turmeric and autoimmune disorders is definitely compelling, but human studies have been far too small - between five and nine people - to form any conclusions. And since autoimmune diseases where the body's own immune system attacks itself are particularly tricky to treat, it's even more important that scientists and healthcare professionals take caution before providing overarching guidance for everyone.
You don't have to eat a lot to reap the rewards. Not only would you need to eat a whole lot of turmeric to get the best benefits, but also curcumin's not a very bio-available compound.
Bioavailability refers to the proportion of a substance you take that has an active effect. Turmeric is technically safe in higher doses, but it's also been linked to some tummy trouble, so take it easy on the powder unless you've been advised otherwise by your doc. Just know that if you're using expensive supplements or blowing through jars of the spice regularly, it can definitely do some damage to your wallet!
It's better absorbed with black pepper. Research has linked piperine - the active compound in black pepper - to better absorption of curcumin in your body. That's why many supplements on the market contain both curcumin and piperine and, in my honest opinion, to also raise the price of the product.
Still, you're better off eating turmeric and pepper in meals instead of in supplement form. The phytonutrients found in plant-based foods also boost absorption of all types of antioxidant-like compounds, which can ultimately improve health overall.
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It's better than other spices. Turmeric has a very distinct taste, making curry and other recipes so darn delicious for some and a total turnoff to others. But since turmeric is still a plant-derived spice, it's important to remember that its benefits are very similar to many other seasonings, including the ones you already in your pantry right now! So if you're not a fan of the taste, there's no reason to start devouring it just yet.
Adding ginger, chili flakes, garlic, pepper, cumin and cinnamon to plant-based recipes can also boost flavor without adding sodium, making it a more nutritious option as a whole. View photos More Taking a turmeric supplement can't hurt.